Table 3.
OR of radiographic osteoarthritis (ROA) using patient-centered definitions. OR data are for each definition of OA, using logistic regression and adjusted for age, sex, and BMI. Bold type indicates statistically significant associations (p ≤ 0.05).
| Marker | Thumb Base OA (KL > 1 in both joints) | MCP OA (KL > 1 in > 1 joint of each hand) | PIP OA (KL > 1 in > 3 joints of each hand) | DIP OA (KL > in > 3 joints of each hand) | Knee OA (KL > 1 both knees) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | |
| Adiponectin | 0.99 | (0.83–1.18) | 1.14 | (0.60–2.19) | 1.54 | (1.04–2.28) | 1.05 | (0.76–1.44) | 1.10 | (0.85–1.43) |
| CD40 (serum) | 1.02 | (0.89–1.17) | 1.38 | (0.85–2.22) | 1.26 | (0.89–1.77) | 1.13 | (0.87–1.47) | 1.22 | (0.99–1.51) |
| CD40 (plasma) | 0.96 | (0.84–1.11) | 0.66 | (0.25–1.73) | 1.18 | (0.86–1.61) | 0.88 | (0.66–1.18) | 0.95 | (0.75–1.21) |
| CRP | 0.97 | (0.85–1.11) | 0.86 | (0.45–1.65) | 1.00 | (0.72–1.38) | 0.68 | (0.47–1.00) | 1.08 | (0.92–1.27) |
| Fibrinogen | 1.00 | (0.86–1.15) | 1.14 | (0.63–2.04) | 1.11 | (0.77–1.61) | 0.77 | (0.58–1.02) | 0.87 | (0.67–1.11) |
| ICAM-1 | 0.96 | (0.84–1.10) | 1.00 | (0.62–1.61) | 1.04 | (0.75–1.43) | 0.91 | (0.70–1.18) | 1.08 | (0.90–1.31) |
| IL-6 | 1.02 | (0.89–1.17) | 1.38 | (1.00–1.89) | 0.76 | (0.43–1.35) | 0.39 | (0.20–0.75) | 0.92 | (0.72–1.19) |
| Isoprostanes | 0.98 | (0.84–1.14) | 0.42 | (0.13–1.34) | 0.97 | (0.64–1.47) | 1.08 | (0.87–1.35) | 1.14 | (0.93–1.40) |
| LP-PLA2 activity | 0.91 | (0.79–1.06) | 0.47 | (0.24–0.94) | 1.18 | (0.80–1.75) | 1.11 | (0.84–1.47) | 1.08 | (0.84–1.38) |
| LP-PLA2 mass | 1.04 | (0.91–1.20) | 0.89 | (0.49–1.62) | 1.20 | (0.84–1.72) | 0.96 | (0.74–1.25) | 0.89 | (0.71–1.13) |
| MCP1 | 0.98 | (0.86–1.12) | 1.18 | (0.89–1.55) | 0.82 | (0.52–1.29) | 1.19 | (1.01–1.40) | 1.10 | (0.93–1.31) |
| MPO | 1.21 | (1.06–1.38) | 0.96 | (0.52–1.79) | 0.96 | (0.62–1.48) | 0.97 | (0.72–1.31) | 1.01 | (0.81–1.27) |
| OPG | 1.00 | (0.87–1.15) | 1.28 | (0.87–1.90) | 0.98 | (0.70–1.38) | 1.05 | (0.83–1.31) | 1.02 | (0.82–1.27) |
| P-selectin | 0.99 | (0.86–1.13) | 0.72 | (0.37–1.39) | 0.71 | (0.47–1.09) | 0.89 | (0.69–1.15) | 1.00 | (0.81–1.23) |
| Resistin | 0.92 | (0.77–1.10) | 0.57 | (0.22–1.45) | 1.13 | (0.75–1.73) | 1.15 | (0.87–1.53) | 0.90 | (0.68–1.19) |
| TNF-α | 1.01 | (0.86–1.17) | 0.71 | (0.22–2.32) | 0.80 | (0.36–1.77) | 0.93 | (0.65–1.31) | 1.04 | (0.86–1.25) |
| TNF-RII | 0.99 | (0.86–1.14) | 1.49 | (1.01–2.20) | 1.01 | (0.73–1.40) | 0.92 | (0.72–1.17) | 0.99 | (0.80–1.23) |
BMI: body mass index; KL: Kellgren and Lawrence grade; CD40: CD40 ligand; CRP: C-reactive protein; ICAM-1:intercellular adhesion molecule-1: IL-6: interleukin 6; isoprostanes: (urinary creatinine)/(8epi-PGF2a); LP-PLA2: lipoprotein-associated phospholipase A2; MCP1: monocyte chemoattractant protein; MPO: myeloperoxidase; OPG: osteoprotegerin; TNF-α: tumor necrosis factor-α; TNF-RII: type II TNF receptor; PIP: proximal interphalangeal; DIP: distal interphalangeal.