Table 4.

Risk of radiographic osteoarthritis (ROA) using number of affected joints as the outcome. Linear regression analysis adjusted for age, sex, and body mass index. Joint score is total number of affected (KL > 1) joints.

Marker	Linear Regression Model (dependent variable = joint score)		Linear Regression Model (dependent variable = log of joint score)
	B Coefficient*	p	B Coefficient**	p
Adiponectin	−0.028	0.86	0.005	0.88
CD40 (serum)	0.227	0.06	0.033	0.16
CD40 (plasma)	0.021	0.86	0.007	0.77
C-reactive protein	−0.053	0.67	−0.004	0.88
Fibrinogen	−0.143	0.26	−0.030	0.23
ICAM-1	0.047	0.69	−0.006	0.80
Interleukin 6	−0.054	0.65	0.007	0.77
Isoprostanes	0.008	0.96	−0.012	0.66
LP-PLA2 activity	−0.042	0.75	−0.033	0.20
LP-PLA2 mass	−0.086	0.47	−0.025	0.28
MCP1	0.085	0.48	0.012	0.61
Myeloperoxidase	0.149	0.21	0.037	0.11
Osteoprotegerin	0.114	0.38	0.009	0.73
P-selectin	−0.085	0.48	−0.002	0.92
Resistin	−0.026	0.86	−0.024	0.41
TNF-α	−0.037	0.79	−0.013	0.64
TNF-RII	0.163	0.20	0.013	0.59

^*Change in no. SD needed to predict 1 additional joint affected.

^**Change in no. SD needed to predict 1 additional log joint affected.

KL: Kellgren and Lawrence grade; CD40: CD40 ligand; ICAM-1: intercellular adhesion molecule 1; IL-6: interleukin 6; isoprostanes: (urinary creatinine)/(8epi-PGF2a); LP-PLA₂: lipoprotein-associated phospholipase A₂; MCP1: monocyte chemoattractant protein; TNF-α: tumor necrosis factor-α; TNF-RII: type II TNF receptor.