Fig. 4.

Vasculopathy is independent of size-mismatch grafting. (A) Donor common carotid artery segments from either WT or Bmal1-KO mice were grafted to littermate control WT mice. Wall thickness was increased in Bmal1-KO:WT common carotid artery grafts, whereas WT:WT homotopic grafts were indistinguishable from naïve common carotid arteries. (Bar: 50 μm.) (B) Although there was no difference in lumen diameter groups, a significant increase in wall thickness was observed in Bmal1-KO:WT carotid grafts (n = 8, WT:WT; n = 8, Bmal1-KO:WT; *P < 0.001).