Table 1. Involvement of the SUMO pathways in DNA repair in yeast.
Protein | SUMO pathway | Function in genome stability |
---|---|---|
Ubc9 | SUMO E2 conjugase | Sister chromatid exchange 37 Resolution of recombination intermediate 27 |
Mms21 | SUMO E3 ligase | Sister chromatid exchange 37 Resolution of recombination intermediate 27 ALT maintenance of telomeres 21 |
Siz1 | SUMO E3 ligase | PCNA sumoylation (recruit Srs2) 44, 45 |
Ulp1 | SUMO protease | Suppression of recombination during replication 56 |
Slx5/Slx8 | STUbL | Maintenance of replication fork stability 25, 53 Alternative lengthening of telomeres 59 |