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. 2011 Jan 25;21(3):421–434. doi: 10.1038/cr.2011.14

Figure 2.

Figure 2

Human histone H3.3 compared with H3.1 and H3.2. Differences between the canonical H3 variants (H3.1 and H3.2) ndash; in purple – and the replacement variant H3.3 – in green – are illustrated. Canonical histone genes are organized in tandem and the cluster HIST1 located on chromosome 6p21 contains 6 histone H1 and 49 core histone genes including 10 histone H3 genes. Canonical histone genes lack introns and are not polyadenylated in contrast to the regular genes coding for H3.3 (H3.3A and H3.3B). The amino acid differences between the canonical H3 and H3.3 are illustrated. H3.3 S31 can be phosphorylated. The motifs SVM and AIG in H3.1/2 and H3.3, respectively, could account for chaperone specificity. We also illustrate the distinct enriched marks in H3 and H3.3 before and after deposition into chromatin.