Figure 7.
TH cell differentiation. NF-κB participates in differentiation of several TH cell types following activation of naive CD4+ TH cells. Differentiation pathways in which NF-κB is implicated are indicated with a green arrow. Key transcription factors in each differentiation pathway are indicated above each arrow, while cytokine responsible for skewing TH cells toward a given pathway are indicated below each arrow. Additional cytokines and transcription factors implicated in several of the pathways are not depicted.