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HECT and RING/U-box single subunit E3 ubiquitin ligases. During the process of protein ubiquitination, ubiquitin forms an intermediate thioester linkage with HECT E3s before transfer to the lysine residue in the substrate protein. RING E3s do not form an intermediate with ubiquitin, rather, RING E3s provide a scaffold to support the direct transfer of ubiquitin from E2 to the substrate protein.
