Table 2. Model estimated proportional change in NVT and overall number of IPD cases from pre- to 10 years post- PCV7 introduction in England and Wales, stratified by six age groups, based on the point estimate of the adjusted number of IPD cases, and 95% CIs represent the range of results obtained when the adjusted number of IPD cases is varied over its 95% CI.

	<5	5–14	15–44	45–64	65+	Total
NVT	136%	74%	87%	87%	87%	90%
95% CI	(84%,161%)	(55%,94%)	(62%,108%)	(62%,108%)	(62%,108%)	(63%,111%)
Melegaro et al. [5]	36%	24%	27%	28%	28%	28%
Overall	−42%	−26%	3%	−1%	−7%	−9%
95% CI	(−55%,−36%)	(−34%,−17%)	(−11%,15%)	(−14%,10%)	(−20%,3%)	(−22%,2%)
Melegaro et al. [5]	−63%	−31%	−21%	−28%	−42%	−38%

The proportional changes in NVT and overall IPD cases from best fitted model in the previous study [5] are included for comparison.