Table 1. Thermodynamic parameters obtained by isothermal titration calorimetry for PDC-109 binding to phsophotidylcholine and phosphatidylglycerol unilamellar vesicles.
| Temperature (°C) | n | K a×10−5 (M−1) | ΔG (kcal.mol−1) | ΔH (kcal.mol−1) | ΔS (cal.mol−1.K−1) |
| DPPC | |||||
| 20 | 18.2 (±3.3) | 0.8 (±0.3) | −6.57 | 0.5 (±0.1) | 23.7 (±0.8) |
| 25 | 14.4 (±1.0) | 1.3 (±0.4) | −6.98 | 0.9 (±0.4) | 26.5 (±1.0) |
| 30 | 7.6 (±1.2) | 2.2 (±0.4) | −7.41 | 5.1 (±0.9) | 41.1 (±2.5) |
| 36 | 7.2 (±0.1) | 20.7 (±8.9) | −8.93 | 5.1 (±0.5) | 45.2 (±2.5) |
| 39* | 6.5 (±0.1) | 24.5 (±6.5) | −9.12 | 5.5 (±0.1) | 46.7 |
| DMPC | |||||
| 10 | 21.6 (±0.2) | 3.9 (±0.8) | −7.24 | 1.2±0.1 | 29.7 (±0.4) |
| 15 | 13.4 (±0.9) | 3.5 (±0.6) | −7.31 | 2.3±0.2 | 33.3 (±0.5) |
| 20 | 7.2 (±0.3) | 4.1 (±1.5) | −7.52 | 4.5±0.5 | 40.8 (±1.8) |
| DMPG | |||||
| 7.4 | 55 | 0.26 (±0.03) | −5.91 | 2.9 (±0.6) | 30.0 (±2.4) |
*Data from a single measurement.
Values reported are averages of results obtained from 2–4 independent experiments with standard deviations indicated in parentheses.