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. 2011 Oct 14;6(10):e26065. doi: 10.1371/journal.pone.0026065

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Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) Inclusion of the calcium chelator, BAPTA (10 mM) in the patch pipette (n = 5) abolished the GBR12783 mediated LTP induction by 2xHFS. B) Inclusion of the PKA inhibitor, KT5720 (100 nM) (n = 5) also blocked the GBR12783 mediated LTP induction by 2xHFS. C) Bar chart summarizing the group effects of GBR12783 on LTP induction using 2xHFS. As illustrated, pretreatment with SCH23390 (black bar), BAPTA (hooped bar), KT5720 (diagonal bar), and U0126 (hatched bar) all fully blocked the GBR12783-facilitated LTP (n = 5 in each case). ** P<0.01. Error bars indicate SEM.