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. 2011 Oct 14;6(10):e26065. doi: 10.1371/journal.pone.0026065

Figure 9. TrkB receptor activation lowers the threshold of LTP induction in the BLA.

Figure 9

A) Application of the TrkB receptor agonist, 7, 8-dihydroxyflavone (500 nM, n = 6) facilitated the induction of LTP by 2xHFS. B) Left, raw data showing a typical PPR response before, and at 10 and 30 min after 2xHFS in the presence of the TrkB agonist. Right, a bar chart illustrating the group data. C) Bar chart summarizing the group effects of TrkB receptor activation on LTP threshold using 2xHFS. Application of BDNF (100 ng/ml, n = 4) for 30 min, mimicked the induction of LTP by 2xHFS induced by 7, 8-dihydroxyflavone. Intracellular application of calcium chelator, BAPTA (10 mM, n = 5, hooped bar) as well as the PKA inhibitor, KT5720 (100 nM, n = 5, diagonal bar) or the selective MEK inhibitor, U0126 (10 µM, n = 4, hatched bar) fully blocked the 7, 8-dihydroxyflavone facilitated LTP. However, incubation with DETC (20 µM, n = 6, striped Bar) did not block this effect. ** P<0.01, * P<0.05. Error bars indicate SEM.