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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: J Invest Dermatol. 2011 Aug 4;131(11):2289–2297. doi: 10.1038/jid.2011.196

Figure 1. Increased hyperplasia and hyperproliferation in UVB exposed epidermis from VDRKO mice.

Figure 1

Wild-type mice exposed to 1 dose of UVB (477 mJ/cm2) show epidermal hyperplasia (A, H&E staining) and increased proliferation (B, PCNA staining), 1h and 24h after treatment with no further increase at 48h. VDRKO mice exposed to the same dose of UVB show significantly more pronounced epidermal hyperplasia (A) at 1h and 24h that continued to increase at 48h. VDRKO epidermis also show increased proliferation (B) comparable to that of wild-type mice at 1h and 24h that continued to increase at 48h. The bars denote 50 μm.