Table 1.
Distribution of HbA1c, Glycated Albumin, Fructosamine, 1,5-AG and CGM-measured Glucose Indices
| Mean±SD | Median (interquartile range) | Range | |
|---|---|---|---|
| N=26 | |||
| HbA1c (%) 1 | 7.7 ± 0.7 | 7.8(7.4, 8.2) | 6.1 to 9.4 |
| Glycated albumin (%) 1 | 22 ± 4 | 23(20, 25) | 16 to 30 |
| Fructosamine (umol/L) 1 | 318 ± 42 | 313 (293, 344) | 241 to 427 |
| 1,5-AG (ug/mL) 1,2 | 4.7 ± 2.2 | 4.2 (3.4, 6.1) | 1.2 to 11.6 |
| N=21 | |||
| Mean glucose (mg/dL) | 168 ± 26 | 170 (143, 185) | 126 to 218 |
| % in range (71 to 180 mg/dL) | 58% ± 13% | 56% (48%, 70%) | 38% to 81% |
| % below 70 mg/dL | 3.7 ± 4.9% | 1.8% (0.6%, 5.0%) | 0.0% to 19% |
| % below 60 mg/dL | 1.3% ± 2.5% | 0.4% (0.0%, 1.4%) | 0.0% to 11% |
| % below 50 mg/dL | 0.2% ± 0.4% | 0.0% (0.0%, 0.1%) | 0.0% to 1.3% |
| Area under curve 70 mg/dL 3 | 0.3 ± 0.5 | 0.1 (0.0, 0.3) | 0.0 to 2.0 |
| Low blood glucose index (LBGI) 4 | 0.9 ± 0.9 | 0.6 (0.2, 1.1) | 0.1 to 3.6 |
| % above 180 mg/dL | 38% ± 15% | 40% (24%, 51%) | 10% to 62% |
| % above 200 mg/dL | 30% ± 14% | 32% (17%, 41%) | 4% to 55% |
| % above 250 mg/dL | 13% ± 9% | 10% (6%, 18%) | 0% to 34% |
| Area under curve 180 mg/dL 5 | 23.9 ± 13.8 | 20.6 (13.3, 30.8) | 1.9 to 54.0 |
| High blood glucose index (HBGI) 6 | 9.0 ± 4.1 | 9.1 (5.6, 11.0) | 2.4 to 17.4 |
| Coefficient variation (%) 7 | 0.39 ± 0.07 | 0.37 (0.35, 0.42) | 0.30 to 0.60 |
| Mean amplitude glucose excursion (MAGE) (mg/dL) 8 | 131 ± 28 | 132 (112, 153) | 79 to 185 |
| Absolute rate of change (mg/dL/min) | 0.77 ± 0.15 | 0.75 (0.70, 0.85) | 0.46 to 1.03 |
1
Abnormal values are as follows: HbA1c >6.0%, glycated albumin >16%, fructosamine >285 umol/L, and 1,5-AG <10.7 ug/dL for males and <6.8 ug/dL for females. Data were provided by the DirecNet Central Laboratory.
2
Mean± SD = 4.7±2.4 for males and for 4.8±1.7 females in this study
3
Total area below 70 mg/dL; reflects both percentage and severity of glucose values in the hypoglycemic range
4
Low blood glucose index (15)
5
Total area above 180 mg/dL.
6
High blood glucose index (15)
7
Standard deviation divided by mean glucose
8
Mean amplitude glucose excursion (16)