Skip to main content
. Author manuscript; available in PMC: 2012 Oct 15.
Published in final edited form as: Cancer Res. 2011 Aug 23;71(20):6338–6349. doi: 10.1158/0008-5472.CAN-11-1291

Figure 5. p38γ is associated with the basal-like BC subtype and impacts metastasis and patient survival.

Figure 5

(A) The basal-like BC subtype is enriched in high (top 25%) compared to low (bottom 75%) p38γ-expressing patients (p = 0.018). (B) Quantification of lymph node metastasis of orthotopically xenografted 231 scrambled and shp38γ cells. Scrambled cells had a significantly higher incidence of metastasis into the contralateral mammary lymph nodes (p = 0.047), as measured by Fisher's exact test. (C) Representative images of 231 scrambled cells invading the ipsilateral lymph node (left) and a metastatic cluster in the contralateral respective mammary gland (right). The intact lymph node capsule is indicated by the arrowhead, while invading scrambled cells are marked by the arrow and magnified in the inset (all scale bars = 100 μm). (D) High p38γ expression is associated with lower overall BC patient survival as determined by Kaplan-Meier analysis (p = 0.013).