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. Author manuscript; available in PMC: 2012 Nov 16.

Published in final edited form as: Eur J Pharmacol. 2011 Sep 2;670(1):252–259. doi: 10.1016/j.ejphar.2011.08.013

Fig. 1 — BK channel activation with NS1619 decreases the spontaneous phasic and tonic contractions of rat DSM isolated strips. A) Representative myograph recording obtained from a spontaneously contracting rat DSM strip before and after the addition of 30 μM NS1619. B) Summary data illustrating that NS1619 decreased the amplitude, muscle force integral, frequency and duration of spontaneous phasic contractions, and muscle tone. n=8, N=7, **P<0.005; *P<0.05. C) A representative myograph recording showing lack of NS1619 (30 μM) effect on the 200 nM IBTX-induced phasic and tonic contractions. D) Summary data illustrating the effect of NS1619 on all contraction parameters in the presence of 200 nM IBTX. n=7, N=3, P<0.05; IBTX versus control (ns= not significant; IBTX versus NS1619). Spontaneous contractions were taken to be 100%. Data are means ± S.E.M.

Fig. 1 — BK channel activation with NS1619 decreases the spontaneous phasic and tonic contractions of rat DSM isolated strips. A) Representative myograph recording obtained from a spontaneously contracting rat DSM strip before and after the addition of 30 μM NS1619. B) Summary data illustrating that NS1619 decreased the amplitude, muscle force integral, frequency and duration of spontaneous phasic contractions, and muscle tone. n=8, N=7, **P<0.005; *P<0.05. C) A representative myograph recording showing lack of NS1619 (30 μM) effect on the 200 nM IBTX-induced phasic and tonic contractions. D) Summary data illustrating the effect of NS1619 on all contraction parameters in the presence of 200 nM IBTX. n=7, N=3, P<0.05; IBTX versus control (ns= not significant; IBTX versus NS1619). Spontaneous contractions were taken to be 100%. Data are means ± S.E.M.