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. Author manuscript; available in PMC: 2012 Nov 16.
Published in final edited form as: Eur J Pharmacol. 2011 Sep 2;670(1):252–259. doi: 10.1016/j.ejphar.2011.08.013

Fig. 3.

Fig. 3

NS1619 inhibits the KCl-induced phasic and tonic contractions in rat DSM isolated strips. A) A representative recording from a rat DSM isolated strip showing the inhibitory effect of NS1619 (30 μM) on 20 mM K+-induced contractions. B) Summary data illustrating that NS1619 (30 μM) decreased the amplitude, muscle force integral, frequency and tone of 20 mM KCl-induced phasic contractions. 20 mM KCl induced contractions were taken to be 100%. n=8, N=6, **P<0.01; *P<0.05. C) Representative myograph recording of DSM strip contracted by 60 mM KCl and the lack of any significant NS1619 effect. D) Differential effects of NS1619 on the muscle tone in presence of low (20 mM K+) and high (60 mM K+) extracellular KCl concentrations (n=6, N=5; ns=not significant). Data are means ± S.E.M.