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. Author manuscript; available in PMC: 2012 Nov 16.
Published in final edited form as: Eur J Pharmacol. 2011 Sep 2;670(1):252–259. doi: 10.1016/j.ejphar.2011.08.013

Fig. 4.

Fig. 4

Inhibitory effect of NS1619 (30 μM) on continuous 20 Hz EFS-induced contractions of DSM isolated strips. A) Representative myograph recordings of EFS-evoked contractions obtained from rat DSM strips before and after the addition of 30 μM NS1619 followed by a washout of the drug. Contractile responses were evoked by repetitive (1/min) EFS (0.75 ms pulse width, 3 s pulse duration, 20 V pulse amplitude). B) Summary data illustrating that NS1619 decreased the peak amplitude, force, duration and tone of 20 Hz EFS-induced contractions n=11, N=7, **P<0.005. The effect of NS1619 on amplitude and duration was significantly reversed after washout of the drug with PSS. #Drug effect vs. washout, n=7, N=5; #P<0.01. Data are means ± S.E.M.