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. Author manuscript; available in PMC: 2012 Nov 16.
Published in final edited form as: Eur J Pharmacol. 2011 Sep 2;670(1):252–259. doi: 10.1016/j.ejphar.2011.08.013

Fig. 5.

Fig. 5

NS1619 (30 μM) decreases the amplitude of the EFS-induced contractions in DSM isolated strips. A) Original trace of EFS-induced (stimulation frequency 0.5–50 Hz) contraction in the absence (control), 35 min after application of 30 μM NS1619 and following washout. B) Frequency-response curve illustrating a decrease in the amplitude of EFS-induced contractions following application of 30 μM NS1619. n=9, N=7, ***P<0.005; **P<0.01; *P<0.05. Washout of NS1619 with PSS showed a partial recovery effect on the amplitude of EFS-induced contractions. n=7, N=7, ###P<0.005; ##P<0.01; #P<0.05. The maximal contraction amplitude at EFS frequency of 50 Hz under control conditions was taken to be 100%. Data are means ± S.E.M.