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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: J Invest Dermatol. 2011 Jul 14;131(11):2281–2288. doi: 10.1038/jid.2011.190

Figure 3. Recombinant Klk6 induces melanoma cell migration and invasion.

Figure 3

Relative migration of MeWo (a) and SKmel23 (b) cells was quantified in a scratch wounding assay at indicated time points. The distance between two migrating cell borders was measured and relative migration is indicated in percentage with closed wounds set to 100%. Black bars represent untreated cells and white bars cells treated with 40 nM recombinant rat Klk6. (c) Relative invasion of SKmel23 cells was measured using BD BioCoat™ Matrigel™ invasion chambers. Invading Klk6-treated (Klk6) and untreated cells (control) were stained with Calcein Fluorescent Dye and measured with the BMG FLUOSTAR Optima device. The number of invading cells in a control experiment was set to one and relative invasion capacity was determined. * P<0.05; ** P≤0.007; *** P<0.0005.