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Measurement of pulmonary mechanics in mice sub-acutely exposed to Cu nanoparticles. Pulmonary mechanics measurements expressed as resistance and compliance in sham- and Cu-exposed mice after increasing concentration of methacholine (1, 3, 10 mg/mL). The mean and SE of resistance and compliance versus methacholine concentrations (A). The individual and mean area under the curve (AUC) versus all increasing methacholine concentrations (B).
