Table 2.
Risk of Treatment Failure: Modified Intention-to-Treat Analysis
| Cumulative risk of recurrencea (95% CI), % |
|||
| Type of recurrence | DP treatment (n = 248) | CQ treatment (n = 244) | Hazard ratiob (95% CI) |
| Plasmodium vivax | |||
| Day 63c | 54.9 (48.2–61.6) | 79.1 (73.4–84.8) | 2.27 (1.8–2.9) (P < .001) |
| Day 28d | 4.1 (1.6–6.6) | 9.8 (5.9–13.7) | 2.3 (1.1–4.9) (P = .032) |
| Plasmodium falciparum | |||
| Day 63d | 8.0 (4.5–11.5) | 11.5 (6.6–16.4) | 1.5 (0.8–2.9) (P = .176) |
| Day 28d | 2.4 (0.4–4.4) | 7.8 (4.3–11.3) | 3.1 (1.2–7.9) (P =. 015) |
Abbreviations: CI, confidence interval; CQ, chloroquine; DP, dihydroartemisinin-piperaquine.
a
Cumulative risk calculated by Kaplan-Meier method. Patients with an incomplete course of treatment were included in the analysis conservatively as treatment failures; other patients with incomplete follow-up were censored on the last day of follow-up as nonfailures.
b
Hazard ratios were calculated using a Cox proportional hazards model.
c
Primary end point.
d
Secondary end point.