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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2011 Oct;70(10):841–858. doi: 10.1097/NEN.0b013e31822f471c

Figure 10.

Figure 10

Developmental changes in the morphology and size of γ-aminobutyric acid (GABA)ergic neurons. (A) At 23 gestational weeks, GABAergic neurons (demonstrated by glutamic acid decarboxylase (GAD65/67) immunocytochemistry) are small and round with scant cytoplasm (arrowhead). (B) At 3 postnatal months they are large with abundant cytoplasm and multiple processes. (C) At 16 postnatal months they have a mature morphology with a granular appearance and without cellular processes. There is punctate GAD65/67 immunostaining in the neuropil at this age. (D) GABAergic neuronal diameters in the frontal association cortex increase significantly with age (p < 0.001, analyzed with age as continuous variable).