Figure 4.
The density of γ-aminobutyric acid (GABA)ergic neurons in the subventricular/ventricular zone (VZ/SVZ) (Box 1), white matter (WM) (Boxes 2–4), and subplate (Box 5) increase between midgestation and term, peak at term, and decline thereafter. This developmental change is statistically significant (p < 0.001). Loess curves demonstrate the changes in GABAergic density for each region (box) from midgestation through infancy. The solid black line in each graph is the best curve fit of the density of GABAergic neurons; gray dotted lines indicate the 95% confidence intervals.