Figure 5.

Percentages of migrating γ-aminobutyric acid (GABA)ergic neurons in the white matter. (A) Densities of GABAergic neurons that express doublecortin (DCX) are expressed as the percent of total GABAergic neuronal density in the periventricular and central white matter in fetal (26–34 gestational weeks), term (37–43 post-conceptional weeks), and infant (3 post-natal months to 2 postnatal years) subjects. The percent of GABAergic migrating neurons decreases significantly after term (ANOVA, p = 0.003). (B–D) A relatively small GABAergic neuron in the white matter expresses both DCX and glutamic acid decarboxylase (GAD65/67) (arrowhead), suggesting that it is migrating. GABAergic neurons that do not express DCX are relatively large with oval cell bodies, intensely staining for GAD65/67, and often have 1 or more processes.