Figure 6.
Migrating γ-aminobutyric acid (GABA)ergic (glutamic acid decarboxylase (GAD65/67-positive, doublecortin (DCX)-positive) neurons in the developing human cerebral cortex and white matter (WM) at 23 post-conceptional weeks (mid-gestation), 38 weeks (term), and 66 weeks (infancy). The density of double positive and GAD65/67-positive, DCX-negative neurons is low in the fetal white matter, increases at term, and decreases in infancy. Double-labeled, migrating GABAergic neurons are rare in the cortex at all ages. GAD65/67 neurons are red; DCX-positive neurons are green; and GAD65/67-positive neurons expressing DCX are yellow (merged, arrows). Blood vessels show as yellow due to autofluorescence, and are not marked by arrows. Scale bar = 200 μm.