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. Author manuscript; available in PMC: 2012 Aug 16.
Published in final edited form as: Oncogene. 2011 Jul 11;31(7):842–857. doi: 10.1038/onc.2011.287

Figure 11.

Figure 11

A&B. Western blotting for β-catenin downstream genes was performed in the whole cell lysates, cytoplasmic extracts or nuclear extracts isolated from Hep3B (A) and Huh7 (B) cells with altered expression of mPGES-1. The levels of c-Myc, cyclinD1 and AKT and were increased in mPGES-1 overexpressed cells but decreased in mPGES-1 depleted cells. The levels of p21WAF/CIP1 and p27KIP1 were decreased when mPGES-1 was overexpressed but increased when mPGES-1 was knocked down. C. Schematic illustration of key mechanisms for mPGES-1-induced HCC growth.