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. Author manuscript; available in PMC: 2012 Aug 16.
Published in final edited form as: Oncogene. 2011 Jul 11;31(7):828–841. doi: 10.1038/onc.2011.277

FIGURE 2. Tumor cell-selective growth arrest by p53-MDM2 interaction inhibition.

FIGURE 2

A, Effects on cellular proliferation following treatment of the indicated cells with Nutlin-3 (5 μmol/L, 60 h). B, Microphotographs showing SA-β-Gal staining of normal melanocytes and SK-Mel-103 melanoma cells treated as indicated. C, Vacuolization and positive blue staining for SA-β-Gal of cells in B. Data correspond to the mean percentage ± SEM of cells from three separate visual fields. D, Protein immunoblots comparing effects of Nutlin-3 (5 μmol/L) and doxorubicin (DOX, 0.5 μg/mL) on the p53-MDM2 pathway in normal melanocytes and the indicated melanoma lines.