Table 1. Case information for Synaptosome Samples.

Cases used for Western analysis. Neuropil threads and plaques are reported for frontal cortex and refer to silver (Gallyas) stain. The plaque number includes plaques with and without cores; sparse (<5/field), mod (6 to 20/field), freq (21 to 30/field). RFU, mean relative fluorescence for Aβ and p-tau antibody fluorescence measured by flow cytometry (mean in superior parietal A7 cortex).

Lane	Sex	Age	PMI (h)	Braak & Braak score	Frontal cortex atrophy	Neuritic plaques	Neurofib. changes (neuropil threads)	amyloid fluor. (RFU)	p-tau fluor (RFU)
Normal cases
1	F	97	5.5	-	mild	0	0	19.73	23.89
2	M	93	8.5	-	mild	0	0	45.16	25.27
3	M	82	14.9	Normal with hippocampal sclerosis	mod	0	0	27.36	26.24
4	F	105	9	-	mod	0	0	23.25	17.19
PD Cases
5	M	74	7.8	PD	mild	0	0	50.35	33.80
6	M	63	3.5	PD vs. Lewy body AD 2 yr dementia	mod	mod	sparse	66.50	25.18
7 tauopathy	F	72	5	dementia	prom	0	marked	43.99	140.96
AD cases
8	F	89	12	IV-V; 10 yr dementia	mild	mod	sparse	79.23	43.07
9	F	87	10	V-VI; 5 yr dementia	mild	freq	mild	145.79	79.84
10	F	80	11	VI; 7 yr dementia	mod	mod	prom	77.11	23.99
11	F	86	5	VI; 11 yr dementia	severe	mod	mod	104.92	58.70
12	M	82	5	VI; mixed AD/Lewy body AD	severe	sparse	sparse	82.71	41.40
13	M	83	7	V; 2 yr dementia	mild	freq	mod	290.95	94.80
14	F	99	11.5	V; 2 yr dementia	mod	sparse	0	74.85	45.64