Table 3.
Cumulative Effects of Gene (Risk Genotypes*)-Environment (GERD, Smoking, and BMI) Interactions on EA Risk: Case-Only Analysis
| Risk Genotypes of rs2295778 and rs13337626 |
GERD | Cumulative ORi (95% CI) |
P | |
|---|---|---|---|---|
| No (n) | Yes (n) | |||
| No risk genotype | 95 | 63 | 1 (reference) | - |
| 1 risk genotype | 62 | 92 | 2.24 (1.42–3.52) | 4.91E-4 |
| 2 risk genotype | 6 | 17 | 4.27 (1.60–11.43) | 3.81E-3 |
| Trend | 2.16 (1.49–3.13) | 4.81E-5 | ||
|
Risk Genotypes of rs2295778 and rs2296188 |
Smoking | Cumulative ORi (95% CI) | P | |
| No (n) | Yes (n) | |||
| No risk genotype | 17 | 28 | 1 (reference) | - |
| 1 risk genotype | 34 | 122 | 2.18 (1.07–4.44) | 3.22E-2 |
| 2 risk genotypes | 15 | 119 | 4.82 (2.15–10.80) | 1.35E-4 |
| Trend | 2.20 (1.47–3.28) | 1.25E-4 | ||
|
Risk Genotypes of rs2114039, rs2296188, rs17619601, rs7324547, rs11941492, rs1770857, and rs17625898 |
BMI≥25 | Cumulative ORi (95% CI) | P | |
| No (n) | Yes (n) | |||
| Risk genotypes ≤3 | 88 | 12 | 1 (reference) | - |
| 4 risk genotypes | 80 | 32 | 2.93 (1.41–6.08) | 3.83E-3 |
| 5 risk genotypes- | 46 | 32 | 5.10 (2.40–10.83) | 2.24E-5 |
| >5 risk genotypes | 17 | 28 | 12.07 (5.15–28.32) | 1.02E-8 |
| Trend | 2.19 (1.70–2.82) | 1.23E-9 | ||
*
SNPs with FDR <0.10 were considered noteworthy.