Table 3.
Clinicopathologic characteristics associated with immunohistochemical staining intensity of epidermal growth factor receptor in primary cutaneous squamous cell carcinoma lesions.
| Variable | % of EGFR staining intensity (No. of Patients) | ||
|---|---|---|---|
| Low* (22) | High † (28) | p value‡ | |
| TMN Stage | |||
| III | 41.3 (19) | 58.7 (7) | 0.31 |
| IV | 75.0 (3) | 25.0 (1) | |
| Nodal Disease | |||
| N0 | 46.2 (12) | 53.8 (14) | 0.78 |
| N+ | 41.7 (10) | 58.3 (14) | |
| Distant Metastatic Disease | |||
| M0 | 41.3 (19) | 58.7 (27) | 0.31 |
| M+ | 75.0 (3) | 25.0 (1) | |
| Surgical Margins | |||
| Negative | 46.4 (13) | 53.6 (15) | 0.78 |
| Positive | 40.9 (9) | 59.1 (13) | |
| Perineural Invasion | |||
| Negative | 48.5 (16) | 51.5 (17) | 0.55 |
| Positive | 35.3 (6) | 64.7 (11) | |
| Radiation Therapy | |||
| Neoadjuvant | 42.9 (6) | 57.1 (8) | 1.00 |
| Adjuvant | 39.3 (11) | 60.7 (17) | |
| Survival in months (median) | (34) | (30) | |
Abbreviation: EGFR, epidermal growth factor receptor
*
Scoring Intensity (0, 1+)
†
Scoring Intensity (2+, 3+)
‡
Calculated using Fisher’s Exact Test