Table 2. Genetic differentiation (F_ST) among major continental groups and HapMap 2 populations in comparison to other data sets.

Gene sets or SNP data sets	Among HapMap 2 populations			Among regions
	YRI vs CEU	YRI vs CHB+JPT	CEU vs CHB+JPT
Telomere biology genes (37 genes, 716 SNPs, N=1168)b	0.136	0.189	0.095	0.095a
Shelterin genes	0.140	0.224	0.148	0.109
Telomerase complex genes	0.130	0.161	0.071	0.072
DNA repair genes	0.154	0.209	0.099	0.107
Helicase genes	0.139	0.196	0.071	0.085
Other telomere-associated genes	0.098	0.144	0.093	0.086
CVD genes (364 genes, 15 559 SNPs, N=270)c	0.139	0.158	0.095	—
Blood circulation and gas exchange genes	0.129	0.158	0.062	—
Lipoprotein metabolism genes	0.144	0.165	0.082	—
Insulin/IGF-mitogen-activated protein kinase kinase/ MAP kinase cascade genes	0.194	0.174	0.138	—
Disease associated SNPs (25 SNPs, N=952)d	—	—	—	0.10a
Innate immune genes (174 genes, 1396 SNPs, N=917)	—	—	—	0.11
Genome-wide autosomal SNP averagee	—	—	—	0.10–0.15

Abbreviations: CEU, Utah; CHB, Han; CVD, cardiovascular disease; IGF, insulin-like growth factor; JPT, Japanese; MAP, mitogen-activated protein kinase; N=number of individuals; SNP, single-nucleotide polymorphism; YRI, Yoruba.

^aAmong the seven geographic regions represented in the CEPH-HGDP panel.

^bSee methods for a description of genes included in each gene set.

^c(Kullo and Ding, 2007)

^d(Myles et al., 2008)

^e(Akey et al., 2002; Shriver et al., 2004, 2005; Weir et al., 2005).