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. Author manuscript; available in PMC: 2013 Jan 15.
Published in final edited form as: Bioorg Med Chem. 2011 Jul 7;20(2):607–613. doi: 10.1016/j.bmc.2011.06.039

Figure 3.

Figure 3

Proposed LMP2 binding mode and derivatization of UK-101. A) Molecular model depicting the binding of UK-101 (stick model) within the catalytic cleft of LMP2 (surface model). B) Structure of UK-101. The alanine side chain at the P2 position is indicated by the blue circle. This side chain was derivatized for the attachment of the fluorescein or BODIPY fluorophore to give UK101-Fluor or UK101-B660.