Table 3.

Relative risk (RR) and 95% confidence intervals (CIs) of renal cell carcinoma according to history of regular use of statin drugs in the Nurses’ Health Study (1994–2008) and the Health Professionals Follow-Up Study (1990–2006)

Variable	Never users	Ever users	Duration of use
			< 4 years	≥ 4 years
Women
Number of cases	118	46	21	25
Age-adjusted RR	1.0	0.96 (0.67–1.36)	0.90 (0.56–1.44)	1.02 (0.65–1.60)
Age and hypertension – adjusted RR	1.0	0.85 (0.59–1.21)	0.80 (0.50–1.28)	0.89 (0.56–1.41)
Multivariate* RR	1.0	0.76 (0.53–1.10)	0.75 (0.47–1.21)	0.77 (0.49–1.23)
Men
Number of cases	82	31	11	20
Age-adjusted RR	1.0	1.26 (0.81–1.94)	0.93 (0.49–1.76)	1.60 (0.94–2.70)
Age and hypertension adjusted RR	1.0	1.07 (0.69–1.66)	0.80 (0.42–1.53)	1.34 (0.79–2.29)
Multivariate* RR	1.0	1.03 (0.66–1.60)	0.80 (0.42–1.53)	1.25 (0.73–2.14)

^*The models were adjusted for the same covariates as the multivariate model in Table 2.