Table 2.

Assessment of menopausal and urinary symptoms by studies included in the systematic review

Authors	Assessment of Menopausal Symptoms	Assessment of Urinary Symptoms	Prevalence/Severity of Urinary Symptoms
Alfano et al., 200642	16 items from BCPT Symptom Checklist	In past year, difficulty with bladder control when laughing or crying and difficulty with bladder control at other times; bother: 0 = not at all to 4 = extremely	Difficulty with bladder control when laughing or crying = 46% (mean severity = 1.8 (0.9)); difficulty with bladder control at other times = 58.2% (mean severity = 1.8 (1.0))
Avis et al., 200436	15 items from BCPT Symptom Checklist	In past 4 weeks, how bothered have you been by difficulty with bladder control when laughing or crying / at other times (1 = not at all to 5 = very much)	Bladder control - laughing: not at all 74.8%, a little 9.9%, somewhat 8.9%, quite a bit 4.0%, very much 2.5%; bladder control - other: not at all 73.9%, a little 14.3%, somewhat 6.4%, quite a bit 3.5%, very much 2.0%; difficulty with bladder control reported as bothersome by less than 30%
Avis et al., 200540	15 items from BCPT Symptom Checklist	In past 4 weeks, how bothered have you been by difficulty with bladder control when laughing or crying / at other times (1 = not at all to 5 = very much)	Difficulty with bladder control (age categories): 25-34 (n=25), 16%; 35-39 (n=41), 22.0%; 40-44 (n=54), 30.2%; 45-50 (n=82), 51.2%; Total N = 202, 35.3%; p = .0007 - problems increased with age
Chin et al., 200946	FACT-ES	In past 7 days, 4 questions about urinary tract symptoms since endocrine therapy; asked to indicate how true a statement was for them: 0 = not at all to 4 = very much	Dysuria, none = 87%, mild (1/2) = 10%, moderate/severe (3/4) = 2%; urinary incontinence, none = 63%, mild (1/2) = 30%, moderate/severe (3/4) = 3%; urinary urgency, none = 57%, mild (1/2) = 27%, moderate/severe (3/4) = 14%; increased urinary tract infections, none = 88%, mild (1/2) = 8%, moderate/severe (3/4) = 4%
Couzi et al., 199531	Investigator-developed questionnaire	In last 4 weeks, difficulty with bladder control	Reported symptom 36% (n = 66 / 183) ; 55% of those reported symptom severity as mild, 22% as moderate, 23% as severe
Ganz et al., 200032	7 items adapted from BCPT Symptom Checklist	In past 4 weeks, how bothered have you been by difficulty with bladder control when laughing or crying / at other times (0 = not at all to 4 = extremely)	Reported “stress urinary incontinence” at baseline = 51% ; 1 reported urinary incontinence only, 8 reported urinary incontinence and hot flashes, 27 reported urinary incontinence, hot flashes, and vaginal dryness; 1 reported urinary incontinence and vaginal dryness; at baseline urinary scale score for all women = 0.59 (0.82); effect of intervention on urinary incontinence not reported separately from menopausal symptoms
Ganz et al., 200234	Items from BCPT Symptom Checklist	In past 4 weeks, how bothered have you been by difficulty with bladder control when laughing or crying / at other times (0 = not at all to 4 = extremely)	Frequency of bladder problems when laughing or crying (P = .003) and at other times (P = .007) increased significantly over time
Ganz et al., 200335	42 items from BCPT Symptom Checklist	In past 4 weeks, how bothered have you been by difficulty with bladder control when laughing or crying / at other times (0 = not at all to 4 = extremely)	Approximations from graph: 25 - 34 years = 21%, 35 - 39 years = 20%, 40 - 44 years = 35%, 45 - 51 years = 38%
Greendale et al., 200133	Items from BCPT Symptom Checklist	In past 4 weeks, difficulty with bladder control when laughing or crying, difficulty with bladder control at other times; bother: 0 = not at all to 4 = extremely	Urinary incontinence score mean = 14.8 (20.2), range = 0 to 100
Gupta et al., 200643	Menopausal Rating Scale with 2xyxweek recall	Urinary problems (difficulty urinating, increased need to urinate, bladder incontinence); severity: 0 = mild to 4 = severe	Reported urinary problems = 55%; reported moderate to severe symptoms = 39%
Land et al., 200437	17 items from existing instruments including the BCPT Symptom Checklist	In past 7 days, bladder problems	CMF versus AC: ratio of the odds of reporting being at least’a little bit bothered by bladder problems = 4.2, 99.8 CI = 1.262, 13.767, p = .0002
Leining et al., 200644	16 items from BCPT Symptom Checklist	In past 4 weeks, how bothered have you been by difficulty with bladder control when laughing or crying / at other times (0 = not at all to 4 = extremely)	Reported loss of bladder control “slightly bothersome or more severe symptoms:” laughter 26%, other 25%
Morales et al., 200438	Leuven Menopause Form	In past 7 days, did you have frequent urination (even at night) and urgency, urine loss when coughing, sneezing and laughing: not at all; yes, with minor inconvenience; yes, with moderate inconvenience; yes, with severe inconvenience; yes, intolerable	Endocrine therapy naive patients (n = 144) prevalence of urinary problems at baseline = 28% (n = 41);urinary problems at baseline (n = 164): tamoxifen first line patients: mild to moderate = 23%; randomized trial of tamoxifen or letrozole patients: mild to moderate = 23%; NSAI first-line patients: mild to moderate = 39%; (N)SAI previous tamoxifen patients: mild to moderate = 25%; urinary problems at 1 month (n = 163): tamoxifen first line patients: mild to moderate = 35%; randomized trial of tamoxifen or letrozole patients: mild to moderate = 28%; NSAI first-line patients: mild to moderate = 43%; (N)SAI previous tamoxifen patients: mild to moderate = 37%; urinary problems at 3 months (n = 162): tamoxifen first line patients: mild to moderate = 36%; randomized trial of tamoxifen or letrozole patients: mild to moderate = 32%; NSAI first-line patients: mild to moderate = 35%; (N)SAI previous tamoxifen patients: mild to moderate = 15%*
Oleske et al., 200439	Symptom Rating Scale (later modified for use in the National Surgical Adjuvant Breast and Bowel Project)	In past 7 days, difficulty in bladder control	Reported symptoms = 39%: mild 25%, moderate 16%, severe 4%
Schover et al., 200645	7 items adapted from BCPT Symptom Checklist	In past 4 weeks, how bothered have you been by difficulty with bladder control when laughing or crying / at other times (0 = not at all to 4 = extremely)	Mean = .67 (1.2) at baseline
Stanton et al., 200541	42 item from BCPT Symptom Checklist	In past 4 weeks, difficulty with bladder control (when laughing or crying); difficulty with bladder control (at other times); presence / absence = 1/0; bother: 0 = not at all to 4 = extremely	Sample 1: 0.52 (.47 to .58); Sample 2: 0.38 (.33 to .43); Sample 3: 0.32 (.28 to .38); Sample 4: 0.40 (.31 to .50)

^*Data also presented for no symptoms and severe to intolerable symptoms

BCPT = Breast Cancer Prevention Trial Symptom Checklist from the National Surgical Adjuvant Breast and Bowel Project

QOL = quality of life

BCS = breast cancer survivors

BC indicates breast cancer

CMF chemotherapy regimen = cyclophosphamide, methotrexate, and 5-fluorouracil

AC chemotherapy regimen = doxorubicin and cyclophosphamide

CI = confidence interval

PCS = Physical Component Summary Score; MCS indicates Mental Component Summary Score

NSAI = non-steroidal aromatase inhibitors

(N)SAI = non-steroidal and steroidal aromatase inhibitors