Table 3.

CRP association with APOE SNPs and haplotypes

SNP	Genotype	n	LS means (SE)	P (add)	P (dom)
rs429358	TT	1415	0.031 (0.050)	4.8E-04	1.0E-04
	TC	252	−0.310 (0.087)
	CC	15	0.104 (0.326)
rs7412	CC	1307	−0.011 (0.051)	0.86	0.95
	CT	340	−0.011 (0.079)
	TT	26	−0.132 (0.250)

Haplotype	rs429358-rs7412	Frequency	Hap-score	P
APOE ε2	T-T	0.116	−0.23	0.81
APOE ε3	T-C	0.799	2.55	0.01
APOE ε4	C-C	0.085	−3.39	7.1E-04

The “haplo.score” function implemented in the “haplo.stats” R package was used to compute score statistics to test association between haplotypes and plasma CRP. Hap-score is the score statistic for the specific haplotype. The global P value for association between haplotypes and CRP level was 2.6 × 10⁻³.