Table 4.

Interaction between genetic variants and pathogen exposure on plasma CRP in 1,709 CLHNS individuals

SNP	Gene	Low pathogen exposure		High pathogen exposure		P (inter)
		β (SE)	P	β (SE)	P
rs876537	CRP	0.220 (0.067)	0.0010	0.345 (0.067)	3.6E-07	0.18
rs7305618	HNF1A	0.181 (0.066)	0.0063	0.348 (0.065)	1.3E-07	0.031
rs429358	APOE	0.333 (0.108)	0.0022	0.256 (0.112)	0.022	0.85
rs1892534	LEPR	0.249 (0.088)	0.0047	0.068 (0.089)	0.44	0.030
rs4129267	IL6R	0.010 (0.081)	0.90	0.144 (0.082)	0.079	0.097
rs1260326	GCKR	0.066 (0.066)	0.32	0.053 (0.069)	0.45	0.69
rs10778213	12q23.2	0.062 (0.077)	0.42	0.010 (0.077)	0.90	0.72
rs1408282	6q16.1	0.226 (0.119)	0.057	0.593 (0.123)	1.5E-06	0.046

Pathogen score < 0.5 (median) was defined as low pathogen exposure (n = 877, 51.3%) while the pathogen score ≥ 0.5 was defined as high pathogen exposure (n = 832, 48.7%); P (inter): P for interaction between genotype and pathogen score on CRP level.