Table 5.
Associations between SNPs and other cardiovascular traits in CLHNS
| SNP (Gene) | BMI | Waist circumference | TG | HDLC | LDLC | Chol | Hcy | |
|---|---|---|---|---|---|---|---|---|
| rs876537 (CRP) | β (SE) | −0.004 (0.006) | −0.163 (0.393) | −0.027 (0.018) | 0.016 (0.009) | 0.014 (0.011) | 0.007 (0.008) | −0.005 (0.009) |
| P | 0.52 | 0.68 | 0.14 | 0.088 | 0.20 | 0.34 | 0.55 | |
| rs3091244 (CRP) | β (SE) | −0.008 (0.007) | −0.497 (0.421) | −0.041 (0.020) | 0.010 (0.010) | 0.023 (0.012) | 0.010 (0.008) | 0.008 (0.010) |
| P | 0.23 | 0.24 | 0.036 | 0.31 | 0.048 | 0.22 | 0.38 | |
| rs7305618 (HNF1A) | β (SE) | −0.002 (0.006) | 0.068 (0.385) | 0.008 (0.018) | −0.005 (0.009) | −0.019 (0.011) | −0.013 (0.007) | −0.012 (0.007) |
| P | 0.78 | 0.86 | 0.65 | 0.61 | 0.065 | 0.090 | 0.10 | |
| rs429358 (APOE) | β (SE) | 0.004 (0.010) | 0.610 (0.641) | −0.022 (0.030) | 0.021 (0.015) | −0.086 (0.017) | −0.049 (0.012) | −0.012 (0.014) |
| P | 0.67 | 0.34 | 0.45 | 0.18 | 6.5E-07 | 7.2E-05 | 0.43 | |
| rs1892534 (LEPR) | β (SE) | −0.004 (0.008) | 0.189 (0.512) | −0.029 (0.024) | 0.004 (0.012) | −0.005 (0.014) | −0.006 (0.010) | 0.002 (0.012) |
| P | 0.60 | 0.71 | 0.23 | 0.76 | 0.74 | 0.52 | 0.88 | |
| rs4129267 (IL6R) | β (SE) | −0.001 (0.008) | 0.061 (0.476) | 0.031 (0.022) | −0.004 (0.011) | −0.004 (0.013) | −0.010 (0.009) | 0.013 (0.011) |
| P | 0.94 | 0.90 | 0.15 | 0.71 | 0.75 | 0.27 | 0.22 | |
| rs1260326 (GCKR) | β (SE) | 0.000 (0.006) | 0.051 (0.392) | 0.049 (0.018) | 0.008 (0.009) | 0.000 (0.011) | 0.008 (0.008) | −0.008 (0.009) |
| P | 0.97 | 0.90 | 0.0064 | 0.42 | 0.95 | 0.28 | 0.38 | |
| rs10778213 (12q23.2) | β (SE) | −0.004 (0.007) | −0.266 (0.447) | 0.008 (0.021) | −0.002 (0.011) | −0.008 (0.012) | −0.002 (0.009) | −0.003 (0.010) |
| P | 0.59 | 0.55 | 0.71 | 0.88 | 0.52 | 0.86 | 0.73 | |
| rs1408282 (6q16.1) | β (SE) | 0.012 (0.011) | 1.117 (0.704) | −0.020 (0.033) | −0.010 (0.017) | 0.005 (0.019) | −0.001 (0.014) | 0.012 (0.016) |
| P | 0.30 | 0.11 | 0.55 | 0.54 | 0.79 | 0.92 | 0.45 |
All traits were natural log-transformed except waist circumference;
TG: triglyceride; HDLC: HDL-Cholesterol; LDLC: LDL-Cholesterol; Chol: total cholesterol; Hcy: homocysteine;
Adjusted for age, household assets, household income (natural log transformed), number of previous pregnancies, pathogen score, infectious status, and PC1-7;