Table 4.

Stop codon versus open reading frame (ORF) in exon 3 of FCGR2C in healthy controls and patients with ITP

FCGR2C exon 3	Number (%) of patients
SNP	Healthy controls (n = 100)	ITP (n = 116)
STOP	6 (6)	4 (3·4)
STOP/STOP	66 (66)	68 (58·6)
STOP/STOP/STOP	10 (10)	4 (3·4)
ORF	1 (1)	2 (1·7)
ORF/ORF	0 (0)	3 (2·6)
ORF/STOP	16 (16)	32 (27·6)
ORF/ORF/STOP	0 (0)	1 (0·9)
ORF/STOP/STOP	1 (1)	2 (1·7)*
	Allele frequency (%)
Allele frequency	Healthy controls	ITP
STOP	186 (91·2)	198 (81·1)
ORF	18 (8·8)	44 (18·9)†

^*ORF single nucleotide polymorphisms (SNPs) healthy versus idiopathic thrombocytopenic purpura (ITP); P = 0·009.

^†ORF allele frequency healthy versus ITP; P = 0·004.