Table 2.

Genome-wide significant single nucleotide polymorphism (SNP)-phenotype associations in genome-wide association analysis of circulating VEGF levels (p<5×10⁻⁸)

SNP	Chr	Position*	Function	CAF	Coded Allele	strand	beta† (FHS)	SE (FHS)	p (FHS)||	p (PIVUS)||	p (SFS)||	Dir	Meta-p (FHS+PIVUS)‡	Meta-p (all)§	Gene1	Distance (kb)	Gene2	Distance (kb)
rs6921438	6	44033585	intergenic	0.51	G	+	0.72	0.01	6.11×10−506	NA	2.93×10−39	-?-	6.11×10−506	4.44×10−524	MGC45491	42.7	MRPL14	155.8
rs4513773	6	44033504	intergenic	0.47	G	+	−0.70	0.01	2.08×10−482	6.23×10−139	NA	++?	4.45×10−619	1.10×10−584	MGC45491	42.8	MRPL14	155.8
rs9472159	6	44027673	intergenic	0.50	C	+	0.76	0.02	4.30×10−452	3.27×10−109	4.11×10−35		1.61×10−557	8.16×10−553	MGC45491	48.6	MRPL14	161.7
rs9369434	6	44026385	intergenic	0.53	C	+	0.84	0.02	2.15×10−442	1.43×10−63	5.31×10−28		1.43×10−490	1.21×10−496	MGC45491	49.9	MRPL14	163.0
rs1776717	6	44059314	intergenic	0.21	A	+	−0.23	0.02	8.10×10−20	3.74×10−4	9.75×10−6		3.28×10−22	1.07×10−26	MGC45491	17.0	MRPL14	130.0
rs1776721	6	43998961	intronic	0.31	T	+	−0.18	0.02	1.52×10−19	3.43×10−8	0.02		5.38×10−26	4.23×10−26	MGC45491	77.3	VEGF	136.8
rs1886979	6	44012879	3′UTR	0.41	G	+	0.17	0.02	3.71×10−19	3.23×10−6	0.01		6.55×10−24	1.70×10−24	MGC45491	63.4	VEGF	150.7
rs9472155	6	44005705	intronic	0.22	T	+	−0.20	0.02	4.45×10−19	3.93×10−9	0.01		2.50×10−26	1.51×10−26	MGC45491	70.6	VEGF	143.5
rs844294	6	44008685	intronic	0.52	C	+	−0.15	0.02	1.19×10−14	2.25×10−5	0.09	+++	1.41×10−18	2.46×10−18	MGC45491	67.6	VEGF	146.5
rs4416670	6	44058431	intergenic	0.55	T	+	0.13	0.02	1.47×10−12	0.10	2.87×10−4	+++	1.44×10−12	2.08×10−15	MGC45491	17.9	MRPL14	130.9
rs910611	6	44058829	intergenic	0.08	C	+	−0.26	0.04	2.61×10−10	6.36×10−6	0.11	+++	9.92×10−15	1.94×10−14	MGC45491	17.5	MRPL14	130.5
rs6993770	8	106650704	intronic	0.32	T	+	−0.17	0.02	2.50×10−16	3.99×10−8	0.02	+++	2.60×10−22	4.71×10−23	ZFPM2	0	LRP12	980.4
rs16873402	8	106658423	intronic	0.33	T	+	−0.15	0.02	1.97×10−14	9.49×10−9	0.16		1.10×10−20	5.32×10−20	ZFPM2	0	LRP12	988.1
rs16873365	8	106627411	intronic	0.22	T	+	−0.16	0.02	5.65×10−12	2.09×10−6	0.37		4.10×10−16	2.27×10−15	ZFPM2	0	LRP12	957.1
rs7013321	8	106662734	intronic	0.49	A	+	−0.14	0.02	6.75×10−12	NA	0.01	-?-	6.75×10−12	4.49×10−13	ZFPM2	0	LRP12	992.4
rs6993696	8	106650460	intronic	0.46	A	+	−0.13	0.02	8.54×10−12	1.49×10−4	0.05		6.18×10−15	2.12×10−15	ZFPM2	0	LRP12	980.1
rs16873291	8	106597206	intronic	0.31	T	+	−0.13	0.02	5.30×10−11	7.65×10−7	0.07		1.12×10−15	4.75×10−16	ZFPM2	0	LRP12	926.9
rs1349319	8	106625810	intronic	0.39	A	+	0.11	0.02	3.59×10−8	1.32×10−3	0.05	+++	1.99×10−10	3.53×10−11	ZFPM2	0	LRP12	955.5
rs10738760	9	2681186	intergenic	0.49	A	+	0.28	0.02	1.96×10−34	1.12×10−8	0.03	+++	4.46×10−41	9.93×10−40	KCNV2	26.3	VLDLR	36.7
rs6475920	9	2663933	intergenic	0.36	A	+	−0.24	0.02	3.76×10−32	2.40×10−8	0.02		6.11×10−39	7.93×10−38	VLDLR	19.4	KCNV2	43.6
rs4741756	9	2658187	intergenic	0.28	C	+	−0.25	0.02	2.95×10−31	8.64×10−5	0.09	+++	4.45×10−34	3.41×10−32	VLDLR	13.7	KCNV2	49.3
rs2375980	9	2682622	intergenic	0.42	G	+	−0.25	0.02	1.30×10−27	2.25×10−8	0.02	+++	2.55×10−34	1.01×10−33	KCNV2	24.9	VLDLR	38.1
rs10122587	9	2681951	intergenic	0.28	T	+	−0.22	0.02	3.02×10−24	NA	0.02	-?-	3.02×x10−24	4.67×10−24	KCNV2	25.6	VLDLR	37.5
rs10967492	9	2671175	intergenic	0.21	A	+	−0.22	0.02	1.02×10−21	NA	0.10	-?-	1.02×10−21	1.25×10−20	VLDLR	26.7	KCNV2	36.3
rs10967470	9	2665698	intergenic	0.24	G	+	−0.22	0.02	1.17×10−21	NA	0.04	+?+	1.17×10−21	2.79×10−21	VLDLR	21.2	KCNV2	41.8

CAF: Coded Allele Frequency; Chr: chromosome; Dir: Direction of association in FHS, PIVUS, SFS; Gene1: closest referenced gene; Gene2: second closest referenced gene; Meta-p: meta-analysis p-value; SNP: Single Nucleotide Polymorphism; CSE: Standard Error;

^*genome build 36.3;

^†effect estimate for the minor allele;

^‡inverse variance meta-analysis;

^§effective sample size weighted meta-analysis;

^||model A: adjusted for age and gender, as well as for the ninth principal component in FHS