Table 3.
Independent Determinants of Baseline PlGF Levels
| Difference in PlGF* | 95% CI | p value | |
|---|---|---|---|
| Demographic Characteristics | |||
| Age (10 year difference) | +0.57 | (0.31, 0.84) | < 0.01 |
| Male (vs female) | +0.98 | (0.34, 1.6) | < 0.01 |
| African American (vs Caucasian) | −3.0 | (−3.8, −2.3) | < 0.01 |
| Medical History and Risk Factors | |||
| History of diabetes (vs none) | +1.1 | (0.40, 1.8) | < 0.01 |
| Heart Failure Characteristics | |||
| Cardiac resynchronization therapy (vs none) | +0.88 | (0.17, 1.6) | 0.02 |
| Medication Use | |||
| ACE inhibitors or ARBs (vs none) | −1.1 | (−2.0, −0.21) | 0.02 |
| Clinical Measures | |||
| Pulse pressure (10 mmHg difference) | +0.43 | (0.23, 0.64) | < 0.01 |
| eGFR (10 ml/min/1.73 m2 difference) | −0.26 | (−0.39, −0.11) | < 0.01 |
| BNP (multiplicative difference of 2) | +0.21 | (0.065, 0.35) | < 0.01 |
*
This column denotes the β coefficient from a multivariable linear regression model for PlGF, and represents the difference in mean PlGF (pg/ml) between each group for categorical or continuous variables. The mean±SD of PlGF was 19.4±6.2 pg/ml