Table 5.

Joint Effects of sFlt-1 and BNP on Risk of All-Cause Death, Cardiac Transplantation, or VAD Placement

sFlt-1*	BNP*	n	HR (95% CI)	p value	HR (95% CI)	p value
Low	Low	482	Referent		Referent
High	Low	219	1.44 (0.86, 2.40)	0.16	1.21 (0.71, 2.14)	0.48
Low	High	219	2.78 (1.84, 4.19)	< 0.01	1.99 (1.30, 3.05)	< 0.01
High	High	483	6.08 (4.36, 8.50)	< 0.01	2.87 (1.96, 4.21)	< 0.01

HR = hazard ratio; CI = confidence interval

^*Low/high sFlt-1 defined as below/above median (308 pg/ml)

^*Low/high BNP defined as below/above median (175 pg/ml)

^**Adjusted for all covariates listed in Table 4, Model 2