Table 3.
Genes Related to Cell Signaling, Synaptic Plasticity and Transcription Regulation
| Gene Symb | Signaling | Synaptic plasticity | Transcription regulation | Addiction | Nicotine | Gene name |
|---|---|---|---|---|---|---|
| ADRBK1 | 345 | 14 | 5 | adrenergic, beta, receptor kinase 1 | ||
| AHI1 | 6 | 2 | Abelson helper integration site 1 | |||
| APBA1 | 15 | 30 | 15 | 1 | amyloid beta (A4) precursor protein-binding, family A, member 1 | |
| CAMK2D | 8 | 2 | 136 | 41 | 15 | calcium/calmodulin-dependent protein kinase II delta |
| CAR8** | 3 | 2 | carbonic anhydrase 8 | |||
| CASK | 30 | 51 | 16 | calcium/calmodulin-dependent serine protein kinase | ||
| DAAM1 | 25 | 2 | dishevelled associated activator of morphogenesis 1 | |||
| DSTN | 37 | 29 | destrin | |||
| EMD | 72 | emerin | ||||
| EPHA5 | 8 | 34 | 2 | EphA5 | ||
| ETFA | 1 | 3 | 1 | electron-transfer-flavoprotein, alpha polypeptide | ||
| GRIA4 | 6 | glutamate receptor, ionotrophic, AMPA 4 | ||||
| GRB10 | 78 | growth factor receptor-bound protein 10 | ||||
| GABRG1** | 1 | gamma-aminobutyric acid (GABA) A receptor, gamma 1 | ||||
| HBP1 | 48 | HMG-box transcription factor 1 | ||||
| HMBOX1 | 4 | homeobox containing 1 | ||||
| HPCAL1 | 6 | 2 | hippocalcin-like 1 | |||
| ILF3 | 35 | interleukin enhancer binding factor 3 | ||||
| MTSS1 | 14 | metastasis suppressor 1 | ||||
| NCAM1 | 277 | 675 | 11 | 5 | neural cell adhesion molecule 1 | |
| NFATC3 | 76 | nuclear factor of activated T-cells, calcineurin-dependent 3 | ||||
| NMI | 15 | N-myc (and STAT) interactor | ||||
| NNAT** | 6 | 1 | neuronatin | |||
| NXPH1 | 5 | 3 | neurexophilin 1 | |||
| POLE3 | 5 | polymerase (DNA directed), epsilon 3 (p17 subunit) | ||||
| PPP1R14A** | 26 | protein phosphatase 1, regulatory (inhibitor) subunit 14A | ||||
| PRDX1 | 44 | peroxiredoxin 1 | ||||
| PSMD7 | 1 | Psmd7 proteasome 26S subunit, non-ATPase, 7 | ||||
| PTAFR | 68 | 10 | platelet-activating factor receptor | |||
| RAD21 | 44 | RAD21 homolog (S. pombe) | ||||
| RICTOR | 90 | 2 | 1 | RPTOR independent companion of MTOR, complex 2 | ||
| RUFY2 | 6 | 4 | 2 | RUN and FYVE domain containing 2 | ||
| SSH2 | 2 | 2 | slingshot homolog 2 | |||
| SNAPC2 | 9 | small nuclear RNA activating complex, polypeptide 2 | ||||
| SPARC | 99 | 21 | secreted protein, acidic, cysteine-rich (osteonectin) | |||
| STXBP3 | 1 | syntaxin binding protein 3 | ||||
| TERF1 | 111 | telomeric repeat binding factor (NIMA-interacting) 1 | ||||
| VLDL-R | 17 | 4 | very low density lipoprotein receptor | |||
| VSNL1** | 14 | 10 | 1 | 2 | visinin-like 1 | |
| ZCCHC12 | 2 | 4 | zinc finger, CCHC domain containing 12 | |||
| ZFP410 | 6 | zinc finger protein 410 | ||||
| Number of genes | 24 | 22 | 18 | 10 | 4 | |
| Median PubMed hits | 14.5 | 3.5 | 15.5 | 1.5 | 3.5 |
**
denotes transcripts also measured by RT-PCR