Figure 7. DegU-P inhibits σ^D indirectly by activating the expression of the anti-sigma factor FlgM.

A model of motility gene regulation in B. subtilis. Open arrows indicate open reading frames. Bent thin arrows indicate promoters. Thick arrows indicate activation. Thick T-bars indicate repression. Heavy gray lines indicate previously published data; heavy black lines indicate the newly proposed model. The dashed line indicates the genetic inference that basal body completion, or the FliF basal body protein, antagonizes DegS by an unknown mechanism.