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. Author manuscript; available in PMC: 2012 Feb 4.
Published in final edited form as: Nature. 2011 Aug 3;476(7358):96–100. doi: 10.1038/nature10237

Figure 1. KIR2DL2 associated sequence polymorphisms result in a loss of NK cell inhibition of HIV replication in vitro.

Figure 1

(A) The Vpu-EnvWT/WT virus was inhibited more robustly by NK cells derived from a KIR2DL2+ individual (gray lines) compared to the Vpu-EnvV/V virus. NK cells derived from a KIR2DL2neg (black lines) individual did not inhibit either virus. (B) Similarly, the Vpu-EnvWT/WT virus was inhibited significantly more strongly by NK cells derived from individuals that expressed KIR2DL2 (dark grey bars, n=6) than the Vpu-EnvV/V virus (black bars). NK cells derived from individuals that did not express KIR2DL2 (white bars, n=6) did not significantly inhibit either virus. * p < 0.05; ** p < 0.005; + KIR2DL2pos; - KIR2DL2neg.