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. Author manuscript; available in PMC: 2012 Sep 16.
Published in final edited form as: Mol Cell. 2011 Sep 16;43(6):853–866. doi: 10.1016/j.molcel.2011.08.017

Figure 2. Connecting APA to cellular proliferative and developmental states.

Figure 2

Enhanced proliferation such as during de-differentiation (e.g., in the generation of iPS cells), T cell activation, or cellular transformation are associated with upregulation in expression of certain 3’ processing factors and with increased usage of proximal poly(A) sites. Late developmental stages and cellular differentiation (e.g. differentiation of C2C12 into myotubes) are associated with downregulation of expression of 3’ processing factors and increased usage of distal poly(A) sites.