Table 2.
Frequency of Different Patterns of CN Alterations for Chromosomes 7, 9, and 10 in Glioblastomas as Detected by SNP Arrays (n = 35)
| Chromosome | Genetic alteration | No. of cases/total cases (%) |
|---|---|---|
| 7 | No alterations | 0/35 (0) |
| CN gains | 34/35 (97) | |
| +7 | 23/35 (65) | |
| +7 and EGFR amplification | 9/35 (26) | |
| EGFR amplification | 1/35 (3) | |
| +7 and other amplifications | 1/35 (3) | |
| cnLOH⁎ | 1/35 (3) | |
| 9 | No alterations | 4/35 (11) |
| CN gains† | 2/35 (6) | |
| CN losses | 28/35 (80) | |
| Heterozygous del(9p) | 4/35 (11) | |
| Heterozygous del(9p) and del(9q) | 2/35 (6) | |
| Heterozygous del(9p) and +9q and 9p gains‡ | 2/35 (6) | |
| Heterozygous and homozygous del(9p) | 12/35 (34) | |
| Heterozygous and homozygous del(9p) and cnLOH§ | 2/35 (6) | |
| Heterozygous and homozygous del(9p) and del(9q) | 2/35 (6) | |
| Heterozygous and homozygous del(9p) and +9q¶ | 1/35 (3) | |
| Heterozygous and homozygous del(9p) and +9q and cnLOH | 2/35 (6) | |
| Monosomy 9 | 1/35 (3) | |
| cnLOH⁎ | 1/35 (3) | |
| 10 | No alterations | 3/35 (9) |
| CN gains | 0/35 (0) | |
| CN losses | 28/35 (80) | |
| −10 | 22/35 (63) | |
| −10 and homozygous del(10q) | 4/35 (11) | |
| del(10p) and del(10q) | 2/35 (6) | |
| cnLOH⁎ | 4/35 (11) |
⁎
cnLOH involving the whole chromosome.
†
Chromosome 9 gains without losses of this chromosome.
‡
Gain of 9p24.3 in one tumor and other gains of 9p21.1 in another case.
§
cnLOH of chromosome 9p was detected in four cases; however, only two are included here (G54 and G55) because the other two cases had +9q21. In one case cnLOH involved the whole chromosome 9.
¶
Two case have cnLOH (G54, G55).