Figure 5.

Mean (±SEM) acetylcholine (ACh) efflux in the medial pre-frontal cortex (mPFC) of postnatal day (PD)7 nDHTTX rats (n=6) and sham controls (n=5) receiving, in pseudo-randomized order, perfusions of vehicle (artificial cerebral spinal fluid aCSF) or N-methyl--aspartate (NMDA) (250 μM) into the dorsal hippocampus (DH) during separate dialysis sessions as adults. The period for baseline infusions of aCSF and administration of NMDA was the same as those reported in previous experiments (Figures 2 and 3). In contrast to the effects seen following inactivation of the ventral hippocampus (VH) (Figure 2), administration of NMDA resulted in robust increases in cortical ACh efflux in both sham and nDHTTX groups (collection nos. 5–8).