Table 3. DOSE × INJECTION Interaction on Peak rCBV Responses to Nicotine.
| Area (number of voxels) |
Group |
Group differences | |||
|---|---|---|---|---|---|
|
1 |
2 |
3 |
4 |
||
| Saline | 0.03 mg/kg | 0.10 mg/kg | 0.30 mg/kg | ||
| Primary cortex | |||||
| Somatosensory | −1.81±0.82a | 0.39±0.96 | 12.67±1.25 | 13.21±1.23 | 3>1, 2; 4>1, 2 |
| (253) | −1.42±0.93b | −1.29±0.76 | 5.80±2.64 | 0.99±2.75 | 3a>3b; 4a>4b |
| Insula | −1.96±0.98 | 0.08±1.47 | 16.49±1.44 | 14.99±1.09 | 3>1, 2; 4>1, 2 |
| (90) | 0.50±1.12 | −0.80±0.84 | 7.44±3.45 | −0.10±3.10 | 3a>3b; 4a>4b |
| Motor | −1.74±0.93 | −0.32±0.79 | 13.97±2.13 | 9.25±1.09 | 3>1, 2; 4>1, 2 |
| (150) | 0.75±0.94 | −0.67±0.40 | 6.32±2.74 | −0.82±2.60 | 3a>3b; 4a>4b |
| Limbic cortex | |||||
| Orbital | −2.13±0.59 | −0.66±1.15 | 12.87±0.99 | 7.49±1.72 | 3>1, 2, 4; 4>1, 2 |
| (104) | 0.54±±0.88 | −1.13±0.62 | 5.40±2.32 | −1.36±2.72 | 3a>3b; 4a>4b |
| Cingulate | −1.01±0.76 | 0.48±1.11 | 18.87±2.76 | 18.26±1.72 | 3>1, 2; 4>1, 2 |
| (125) | −1.60±1.20 | −0.65±0.81 | 9.29±3.65 | 1.55±3.08 | 2>1; 3a>3b; 4a>4b |
| RSDG | −1.81±0.61 | 0.26±0.63 | 14.13±2.30 | 14.52±1.99 | 3>1, 2; 4>1, 2 |
| (122) | −1.36±1.01 | −1.33±0.48 | 7.40±3.23 | 1.40±2.83 | 3a>3b; 4a>4b |
| Olfactory bulb | −2.07±1.78 | −5.70±1.37 | 9.56±1.42 | 4.59±1.50 | 3>1, 2; 4>1, 2 |
| (35) | 0.26±1.78 | 0.94±1.63 | 3.89±1.93 | −1.96±1.47 | 2a>2b; 3a>3b; 4a>4b |
| Thalamus | −2.09±0.31 | −0.79±0.63 | 9.39±1.19 | 7.52±1.37 | 3>1, 2; 4>1, 2 |
| (33) | −0.61±1.01 | −0.88±0.76 | 5.07±2.23 | −0.25±1.80 | 3a>3b; 4a>4b |
Abbreviations: mPFC, medial prefrontal cortex; RSDG, retrosplenial dysgranular and granular cortices.
ANOVA results of the 4 (DOSE) × 2 (INJECTION) interactions of nicotine administration. Values represent the percentage change observed in peak CBV values relative to each injection baseline. The upper and lower values represent the 1st and 2nd injections as shown by the exemplary superscripts a and b, respectively. Significant group differences were thresholded at p<0.05 after Bonferroni correction. Values represent the mean±SEM for each group. Note the primary cortical distribution of effects.