Table 2. Continuous Performance Test Performance as a Function of Cannabis Use and AKT1 rs2494732 Genotype.
|
Cannabis use preceding onset of psychosis (n=601)a | |||||||
|---|---|---|---|---|---|---|---|
|
T/T |
C/T |
C/C |
p interaction | ||||
| Never use (n=103) | Use (n=107) | Never use (n=125) | Use (n=152) | Never use (n=40) | Use (n=74) | ||
| CPT, accuracy (%) (SD) | 92.6 (11.0) | 94.4 (8.7) | 95.3 (8.5) | 95.4 (6.7) | 94.4 (11.4) | 91.6 (14.9) | 0.003 |
| CPT, reaction time (ms) (SD) | 434.9 (76.9) | 412.3 (79.5) | 437.5 (87.5) | 434.1 (82.5) | 425.5 (84.7) | 439.1 (92.2) | 0.037 |
| CPT, false alarms (n) (SD) | 1.16 (4.2) | 0.81 (3.4) | 0.44 (0.8) | 1.01 (4.9) | 0.63 (1.4) | 2.05 (7.0) | 0.455 |
|
Cannabis use preceding onset of psychosis and absence of recent use (N=408)b | |||||||
|
T/T |
C/T |
C/C |
p interaction | ||||
| |
Never use (n=103) |
Former use (n=51) |
Never use (n=125) |
Former use (n=64) |
Never use (n=40) |
Former use (n=25) |
|
| CPT, accuracy (%) (SD) | 92.6 (11.0) | 94.0 (8.3) | 95.3 (8.5) | 96.4 (6.3) | 94.4 (11.4) | 90.6 (16.7) | 0.006 |
| CPT, mean reaction time (ms) (SD) | 434.9 (76.9) | 423.5 (88.9) | 437.5 (87.5) | 429.8 (88.9) | 425.5 (84.7) | 467.1 (85.6) | 0.044 |
a
Genotyping failed in 10 patients.
b
Patients without current use: reported no use of cannabis in the last year and urinalysis confirmed the absence of current cannabis use.