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. 2011 Aug 3;36(12):2561–2570. doi: 10.1038/npp.2011.144

Figure 6.

Figure 6

Effect of protein kinase A (PKA) signaling on ribosomal protein S6 (rpS6) phosphorylation. Western blot analysis of phospho-Ser235/236-rpS6 in striatal neurons in culture. Top panels show representative autoradiograms. Bottom panels are a summary of data represented as means±SEM (n=4). (a) Striatal neurons were treated for 15 min with vehicle (Veh), the A2AR agonist 5′-(N-cyclopropyl)carboxamidoadenosine (CPCA, 10 μM) or CPCA plus the PKA inhibitor H-89 dihydrochloride hydrate (50 μM, added 15 min before CPCA). (b) Striatal neurons were treated for 15 min with Veh or the cAMP analog Sp-5,6-DCl-cBIMPS (cBIMPS, 200 μM). (**p<0.01 vs Veh; °°p<0.01 vs CPCA).